Exhaled Nitric Oxide: A New Lung Function Test

Exhaled nitric oxide: a new lung function test.

Nitric oxide (NO) is a gas molecule produced endogenously in the lungs. It can be detected in the exhaled air of animals and humans. Nitric oxide can be generated in the air passages by a synthase which is induced in several cell types by exposure to proinflammatory cytokines. Its induction is blocked by glucocorticoids. An increased concentration of nitric oxide can be found in the exhaled air...

Exhaled Nitric Oxide

Characterization of exhaled nitric oxide: introducing a new reproducible method for nasal nitric oxide measurements.

Nitric oxide (NO) is present in the human nasal airways and has been suggested to originate primarily from the paranasal sinuses. The aim of this study was to establish a new and reproducible method for measurement of nasal NO. Through repeated single-breath measurements the intra- and inter-individual variations of NO levels in nasally (into a tightly fitting mask covering the nose) and orally...

Exhaled nitric oxide from lung periphery is increased in COPD.

Single constant flow exhaled nitric oxide (eNO) cannot distinguish between the sources of NO. The present study measured eNO at multiple expired flows (MEFeNO) to partition NO into alveolar (Calv,NO) and bronchial (Jaw,NO) fractions to investigate peripheral lung contribution to eNO in chronic obstructive lung disease (COPD). MEFeNO were made in 81 subjects including 18 nonsmokers, 16 smokers a...

Exhaled Nitric Oxide in Systemic Sclerosis Lung Disease

Background. Exhaled nitric oxide (eNO) is a potential biomarker to distinguish systemic sclerosis (SSc) associated pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD). We evaluated the discriminative validity, feasibility, methods of eNO measurement, and magnitude of differences across lung diseases, disease-subsets (SSc, systemic lupus erythematosus), and healthy-controls...